Professional Experience

Lead and support bioinformatic and statistical pipeline development initiatives aimed at generating new data and enabling existing data to create an enriched data resource for real-world clinical studies and publications utilizing Labcorp's precision oncology assays
Work closely with internal and external oncologists, pathologists and scientists within and outside of Labcorp Oncology to create analysis plans and perform bioinformatic and statistical data analyses for real-world clinical studies utilizing Labcorp’s precision oncology assays
Provide support for novel biomarker discovery initiatives through analysis of genomic and transcriptomic data derived from NGS-based genomic and immune profiling
Act as subject matter expert and provide expertise for bioinformatic and statistical analysis of omics data

Provide support for bioinformatics, data analytics, and writing of peer-reviewed research manuscripts for metagenomic-based research projects focusing on the role of the gut microbiome in Parkinson's disease

Bioinformatically processed shotgun metagenomic sequences from human and mouse fecal samples using a variety of tools for quality control of NGS reads and profiling of microbial abundances and genes/pathways
Quality controlled, imputed, and analyzed genome-wide genetic variant data comprised of >60M genetic variants for thousands of subjects using a variety of tools and statistical analyses (GWAS, interaction analysis)
Quality controlled, cleaned, and managed (in electronic database) human subject data with >100 data points from questionnaires and electronic medical records
Performed statistical analyses spanning multiple fields (statistical genetics, microbial ecology, epidemiology, biostatistics) on processed microbial, genetic, and/or subject metadata to investigate research questions
Acted as bioinformatic analytic representative for the UAB site in the international MiBioGen consortium
Contributed to writing and publishing of findings in peer-reviewed journals
Presented findings at institutional and national meetings to both lay and technical audiences

Bioinformatically processed amplicon sequences of bacterial/archaeal 16S rRNA gene from human fecal samples using DADA2 and other R packages and programs to infer taxa presence, abundances, and phylogenetic relatedness
Quality controlled, imputed, and analyzed genome-wide genetic variant data using a variety of tools and statistical analyses (GWAS, interaction analysis)
Quality controlled, cleaned, and managed (in electronic database) human subject data with >100 data points from questionnaires and electronic medical records
Assisted with intake, quality control, cleaning, and management of subject data with >100 data points from questionnaires and electronic medical records
Performed statistical analyses spanning multiple fields (statistical genetics, microbial ecology, epidemiology, biostatistics) on processed microbial, genetic, and/or subject metadata to investigate research questions
Acted as bioinformatic analytic representative for the UAB site in the international MiBioGen consortium
Contributed to the writing and publishing of findings in peer-reviewed journals
Presented findings at institutional, regional, national, and international meetings to both lay and technical audiences

Extracted DNA from buccal swabs of human volunteers using spin column based DNA extraction methods
Isolated and amplified the hypervariable region II (HVII) of human mitochondrial DNA using PCR
Sequenced HVII amplicons using Sanger sequencing and next generation sequencing (NGS)
Evaluated ability of NGS to reproducibly detect heteroplasmy in the HVII region of mitochondrial genome
Compared HVII sequences derived from Sanger sequencing and NGS to determine ability of NGS to detect heteroplasmy

Processed samples sent to the CODIS laboratory including data entry into the CODIS database
Performed laboratory work including blood sample preparation, calibration of instruments, reagent preparation, and PCR